Antithymocyte globulin and antilymphocyte globulin treatments in two cases of severe aplastic anemia.
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چکیده
منابع مشابه
Antithymocyte globulin and transplants for aplastic anemia.
have completed a study on the use of antithymocyte globulin (ATG) as part of the conditioning regimen for severe aplastic anemia (SAA) patients, undergoing an allogeneic stem cell transplant (HSCT) from matched sibling (MSD) or unrelated (UD) donors. The Authors have found that rabbit ATG (thymoglobulin, Sanofi, France), as compared to horse ATG (ATGAM, Pfizer, USA) is associated with less acut...
متن کاملHorse versus rabbit antithymocyte globulin in acquired aplastic anemia.
BACKGROUND In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells. Immunosuppressive therapy with antithymocyte globulin (ATG) plus cyclosporine is an effective alternative to stem-cell transplantation and improves blood counts and survival. Although horse ATG is the standard therapy, rabbit ATG is more pot...
متن کاملAntilymphocyte Globulin, Cyclosporin, and Granulocyte Colony-Stimulating Factor in Patients With Acquired Severe Aplastic Anemia (SAA):
Patients with severe aplastic anemia (SAA) and a neutrophil (PMN) count of less than 0.5 x 109/L are exposed to a high risk of early mortality when treated with antilymphocyte globulin (ALG) and steroids, with the major problem being infectious complications. The addition of human recombinant granulocyte colony-stimulating factor (rhG-CSF) to ALG may reduce early mortality by improving neutroph...
متن کاملIn vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia.
We recently reported that rabbit antithymocyte globulin was markedly inferior to horse antithymocyte globulin as a primary treatment for severe aplastic anemia. Here we expand on our findings in this unique cohort of patients. Rabbit antithymocyte globulin was detectable in plasma for longer periods than horse antithymocyte globulin; rabbit antithymocyte globulin in plasma retained functional c...
متن کاملGraves disease following rabbit antithymocyte globulin treatment of severe aplastic anemia in a Korean child
Antithymocyte globulin (ATG) is used as an immunosuppressive treatment (IST) to deplete clonal suppressor T cells in patients with severe aplastic anemia (SAA). The depletion of suppressor T cells by ATG may affect the activation of B cells, which results in an increased risk for autoimmune conditions. A 12-year-old boy was diagnosed with idiopathic SAA. As he did not have an human leukocyte an...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 1988
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.77.1056